|1 Course of HIV-1 Disease
infection there is a decline in CD4+ cell count, an increase in the plasma
HIV RNA and an increase in the HIV antibodies. During clinical latency, the antibody level
begins to fall, the CD4+ cell count is stable. Viral clearance and production of new
virions is fairly constant. As the
symptoms progress to AIDS the CD4+ cell count decreases, the plasma HIV RNA
increases and the HIV antibody concentration decreases.