resistance and why is it a concern?
|w“HIV drug resistance” describes a loss of HIV
susceptibility to the antiviral activity of one or more drugs.
|wResistant strains of HIV emerge under antiretroviral
therapy and undermine the efficacy of the whole treatment regimen, ultimately
resulting in rebound of plasma viraemia.
|wDrug resistance is a major cause of regimen failure and
restricts the overall duration of effective therapy by steadily eroding the
drug options available.
|wResistant strains can also be transmitted from one person
to another and can therefore restrict the options even in those who have yet
to begin treatment.